Download Ebook Protein Conformational Dynamics 805 (Advances in Experimental Medicine and Biology)
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This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events. Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Intrinsically unstructured proteins and their functions ... Figure 1 The continuum of protein structure. The upper panels show examples on the continuum of protein structure: that is an unstructured conformational ensemble ... Research Outcome for the Faculty of Agriculture and ... Research Outcome for the Faculty of Agriculture and Veterinary Medicine in the Qaseem University Please note that: the system updates the data every one hour thus ... A Controlled Trial of a Human Papillomavirus Type 16 Vaccine Original Article. A Controlled Trial of a Human Papillomavirus Type 16 Vaccine. Laura A. Koutsky Ph.D. Kevin A. Ault M.D. Cosette M. Wheeler Ph.D. Darron R ... Alzheimer's Disease NEJM This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of ... Le Live Marseille : aller dans les plus grandes soires ... Retrouvez toutes les discothque Marseille et se retrouver dans les plus grandes soires en discothque Marseille.
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